PREPARATION OF SOME SUBSTITUTED GUANIDINES
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چکیده
منابع مشابه
Nω-nitro-nω'-substituted Guanidines: a Simple Class of Nitric Oxide Synthase Inhibitors.
A series of Nω-nitro-Nω'-substituted guanidines has been prepared as potential inhibitors of the human Nitric Oxide Synthase (NOS) isoforms. The reported utility of aminoguanidine and nitroarginine in iNOS inhibition points to a potential similar utility for analogs of nitro-guanidine. The compound library was tested against the three isoforms of Nitric Oxide Synthase (eNOS, iNOS and nNOS). Sev...
متن کاملThe occurrence of guanidinoacetic acid and other substituted guanidines in mammalian liver.
Lardy, H. A. & Adler, J. (1956). J. biol. Chem. 219, 933. Long, C. (1952). Biochem. J. 50, 407. McAnnally, R. A. & Phillipson, A. T. (1942). J. Physiol. 101, 14. McKenzie, H. A. & Wallace, H. S. (1954). Aust. J. Chem. 7, 55. Pennington, R. J. (1952). Biochem. J. 51, 251. Pennington, R. J. (1954). Biochem. J. 56, 410. Pennington, R. J. & Sutherland, T. M. (1954). Biochem. J. 58, vii. Pennington,...
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Several l ,3,5-triaza-2-boracyclohexa-4,6-diones, which are isoelectronic analogs of substituted uracil, have been prepared by condensation reactions of boranes with biurets. They include species containing a N H or B H unit as potentially reactive sites. The latter are extremely sensitive to hydrolysis but are readily handled as the 2-methylaminoethanol derivative containing fourcoordinate boron.
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6-Azidoflavins, 6-thiocyanatoflavins, and 6-mercaptoflavins at the lumiflavin, riboflavin, FMN, and FAD level were prepared from the corresponding 6-aminoflavins and some of their properties investigated. They are bound tightly by apoflavin enzymes which bind either riboflavin, FMN, or FAD. 6-Azidoflavins undergo facile photolysis. One major product was identified as 6-aminoflavin. A further pr...
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eernpounds,2) This prompted us to devise a general synthetic method for N-substituted 4-arylpyrrolones. rv-Unsubstituted 4-(4-chlorophenyl)pyrrolone has been prepared from 4-bromo-3-(4-chlorophenyl)-2-butenoic acid with a largc excess ammonia water,i) However, the application of this method, using excess arnines in an aqueous so[ution, would be Iimited, rv-Substitutcd arylpyrrelones may be prep...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1928
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)83859-5